The NFLPA Collegiate Bowl has a rich history of talent. In the ten years since the Collegiate Bowl was first played, the game has had numerous, highly-skilled athletes take the field and go on to have solid NFL careers. The list below highlights some of those stellar alums:
| First Name | Last Name | Position | Current Team |
| Jamal | Agnew | DB | Jacksonville Jaguars |
| Troy | Apke | DB | Washington Football Team |
| Denico | Autry | DL | Tennessee Titans |
| Kelvin | Beachum | OL | Arizona Cardinals |
| Tarik | Cohen | RB | Chicago Bears |
| Chris | Conley | WR | Houston Texans |
| Korey | Cunningham | OL | New York Giants |
| Will | Dissly | TE | Seattle Seahawks |
| Nick | Easton | OL | |
| Samson | Ebukam | LB | San Francisco 49ers |
| Shaquill | Griffin | DB | Jacksonville Jaguars |
| Duron | Harmon | DB | Atlanta Falcons |
| Deonte | Harris | RET | New Orleans Saints |
| Phil | Haynes | OL | Seattle Seahawks |
| Troy | Hill | DB | Cleveland Browns |
| Marquette | King | PT | |
| Josh | Lambo | PK | |
| Darnell | Mooney | WR | Chicago Bears |
| Matt | Paradis | OL | Carolina Panthers |
| Elandon | Roberts | LB | Miami Dolphins |
| L'Jarius | Sneed | DB | Kansas City Chiefs |
| Grover | Stewart | DL | Indianapolis Colts |
| Khyri | Thornton | DL | |
| Nick | Tiano | QB | |
| Marquez | Valdes-Scantling | WR | Green Bay Packers |
| Terrell | Watson | RB | |
| Avery | Williamson | LB | |
| Luke | Willson | TE | |
| Damien | Wilson | LB | Jacksonville Jaguars |
| Antwaun | Woods | DL | Indianapolis Colts |