The NFLPA Collegiate Bowl has always had a rich history of bringing in talented and experienced coaches to guide players through practice week and the game. Below are the coaching staffs of the National and American teams for the 2022 Collegiate Bowl.
| 2022 NATIONAL COACHING STAFF | NAME |
| Head Coach: | Marvin Lewis |
| Offensive Coordinator: | Johnathan Hayes |
| Defensive Coordinator: | Rod Woodson (HOF) |
| Quarterbacks Coach: | Jeff Blake |
| Running Backs Coach: | Patrick Cobbs |
| Wide Receivers Coach: | Terrance Mathis |
| Wide Receivers Coach: | Derek Hagan |
| Tight Ends Coach: | Anthony Becht |
| Offensive Line Coach: | Jackie Slater (HOF) |
| Offensive Line Coach: | Willie Anderson |
| Defensive Line Coach: | Marcus Lewis |
| Linebackers Coach: | Vontaze Burfict |
| Defensive Backs Coach: | Carnell Lake |
| Defensive Backs Coach: | Brock Marion |
| Defensive Backs Coach: | Dante Marsh |
| Special Teams Coach: | Josh Cribbs |
| Specialist/Assistant: | Michael Fletcher |
| Offensive Coaching Intern: | Willie Wright |
| Defensive Coaching Intern: | Benny Sapp |
| Intern: | Andy Rinehart |
| GA: | Steven Beard |
| 2022 AMERICAN COACHING STAFF | NAME |
| Head Coach: | Jeff Fisher |
| Offensive Coordinator: | Duane Taylor |
| Defensive Coordinator: | Wade Phillips |
| Quarterbacks Coach: | Seneca Wallace |
| Running Backs Coach: | Robert Edwards |
| Wide Receivers Coach: | Nate Washington |
| Wide Receivers Coach: | Chris Chambers |
| Tight Ends Coach: | Brandon Manumaleuna |
| Offensive Line Coach: | Eugene Chung |
| Offensive Line Coach: | Lance Zeno |
| Defensive Line Coach: | Andre Gurode |
| Defensive Line Coach: | Aldon Smith |
| Linebackers Coach: | Joe Bowden |
| Defensive Backs Coach: | Darrin Walls |
| Defensive Backs Coach: | Arturo Freeman |
| Special Teams Coach: | Keith Burns |
| Specialist/Assistant: | Nick Novak |
| Offensive Coaching Intern: | Vincent Johnson JR. |
| Defensive Coaching Intern: | John Mac |
| Active Player Intern: | Chris Rowland |
| GA: Ops | Morgan Ford |